PD-89211 is a selective dopamine D4 receptor antagonist with a K i value of 3.7 nM. PD-89211 reverses Quinpirole ( HY-B1752A )-induced [3H]thymidine uptake in CHOpro5 cells ( IC 50 = 2.1 nM). PD-89211 regulates dopamine/norepinephrine metabolism in the hippocampus and can be used for research on central nervous system disorders such as schizophrenia.
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