PV1115 is a potent and highly selective Chk2 inhibitor with an IC 50 of 0.14 nM, 66000 nM, >100000 nM for Chk2 , Chk1 and RSK2 , respectively. PV1115 is situated within the ATP-binding pocket of Chk2 .
Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Checkpoint Kinase (Chk)
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