Rohitukine

Overview

Rohitukine is an orally active CDK9/T1 inhibitor with an IC 50 of 0.3 μM. Rohitukine blocks ATP binding sites of CDK2/A and CDK9/T1 , suppresses PPARγ , AKT , mTOR , C/EBPα , SREBP-2 , and NF-κB signaling, and increases hepatic LXRα expression . Rohitukine induces S-phase cell cycle arrest, ROS generation, apoptosis , and exhibits anti-inflammatory activity. Rohitukine can be used for the research of leukemia, pancreatic cancer , prostate cancer , breast cancer , CNS cancer , ovarian cancer , lung cancer , dyslipidemia, inflammatory diseases, inflammatory bowel disease, and arthritis.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Ovarian Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Arthritis | Products > Disease Areas > Inflammatory Bowel Disease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > CDK | Products > Signaling Pathways > PPAR | Products > Signaling Pathways > Akt | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > LXR | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Wnt | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > ERK | Products > Signaling Pathways > JNK

Product Information

• Catalog No.: HY-119831
• CAS No.: 71294-60-5
• Molecular Formula: C16H19NO5
• Molecular Weight: 305.33
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source