BMS-986169

Overview

BMS-986169 is an inhibitor of the glutamate N-methyl-D-aspartate 2B receptor ( GluN2B ). BMS-986169 has a high binding affinity for the allosteric regulatory site of the GluN2B subunit, with a K i value of 4.03-6.3 nM. BMS-986169 can inhibit the function of GluN2B receptors in Xenopus oocytes, with an IC 50 value of 24.1 nM. BMS-986169 can also inhibit the activity of the hERG channel, with an IC 50 value of 28.4 μM. BMS-986169 can be used in research on treatment-resistant depression.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > iGluR

Product Information

• Catalog No.: HY-119886
• CAS No.: 1801151-08-5
• Molecular Formula: C23H27FN2O2
• Molecular Weight: 382.47
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source