NSC666715

CAS No.：170747-33-8
Grade：99.98%
Formula：C15H13Cl2N5O2S2
M.W.：430.33

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

NSC666715 is a DNA polymerase β ( Pol-β ) inhibitor. NSC666715 directly and specifically interacts with Pol-β , interferes with its binding to damaged DNA , blocks its dRP lyase activity, and inhibits Pol-β -mediated SN- and LP-BER . NSC666715 induces AP site accumulation and S-phase cell cycle arrest, and triggers senescence and apoptosis ( apoptosis ) via the p53 / p21 pathway in colorectal cancer cells. NSC666715 enhances TMZ ( HY-17364 )-induced DNA damage, senescence and apoptosis , and potentiates the cytotoxicity of TMZ. NSC666715 inhibits tumor growth in colon cancer xenograft models. NSC666715 can be used in research related to colorectal cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PARP | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Caspase

Product Information

Catalog No.: HY-120105
CAS No.: 170747-33-8
Molecular Formula: C15H13Cl2N5O2S2
Molecular Weight: 430.33
Purity: 99.98%
Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source

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