LP-922761

Overview

LP-922761 is a potent, selective and orally active adapter protein-2 associated kinase 1 ( AAK1 ) inhibitor with IC 50 s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 also inhibits BMP-2-inducible protein kinase (BIKE) with an IC 50 of 24 nM. LP-922761 exhibits no significant activity at cyclin G-associated kinase (GAK) , opioid, adrenergic α2 or GABAa receptors.

Application

Products | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Lung Fibrosis | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > AAK1

Product Information

• Catalog No.: HY-120179
• CAS No.: 1454808-95-7
• Molecular Formula: C21H26N6O3
• Molecular Weight: 410.47
• Purity: 98.21%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Availability: In-stock

Source

Original product source