PF-04217903 mesylate

Overview

PF-04217903 mesylate is an orally active, highly selective ATP-competitive c-Met kinase inhibitor with a K i value of 4.8 nM and a K d value of 4.5 nM. PF-04217903 mesylate blocks c-Met and HGF signaling pathways, inhibits MET phosphorylation, and blocks downstream MAPK , PI3K/AKT and PLCγ1 pathways. PF-04217903 mesylate suppresses tumor proliferation, survival, migration, invasion, angiogenesis and metastasis, induces apoptosis , and enhances efferocytosis, Annexin A1 expression and resolution of inflammation. PF-04217903 mesylate retains activity against several c-Met mutants (M1131T, V1220I, H1094R). PF-04217903 mesylate increases the incidence of subarachnoid hemorrhage and reduces survival rate without altering aneurysm formation, and also prevents lymph node metastasis induced by VEGF inhibition. PF-04217903 mesylate is applicable to research related to tumors (pancreas, stomach, lung, brain, colon, breast, kidney, melanoma, etc.), intracranial aneurysms and inflammatory diseases (gouty arthritis, neutrophilic pleuritis).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > CNS Neoplasm | Products > Disease Areas > Glioma | Products > Disease Areas > Cerebrovascular Disease | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Gastric Cancer | Products > Disease Areas > Thyroid Cancer | Products > Disease Areas > Thyroid Disease | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Melanoma | Products > Disease Areas > Arthritis | Products > Disease Areas > Non-Small Cell Lung Cancer | Products > Disease Areas > Glioblastoma | Products > Disease Areas > Subarachnoid Hemorrhage | Products > Disease Areas > Aneurysm | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Phospholipase | Products > Signaling Pathways > Annexin A | Products > Signaling Pathways > c-Met/HGFR | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Akt

Product Information

• Catalog No.: HY-12017A
• CAS No.: 956906-93-7
• Molecular Formula: C20H20N8O4S
• Molecular Weight: 468.49
• Purity: 99.82%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 3 mg/mL (6.40 mM); Clear solution
• Availability: In-stock

Source

Original product source