YF-452

Overview

YF-452 is a potent inhibitor of vascular endothelial growth factor receptor 2 ( VEGFR2 ). YF-452 remarkably inhibits the migration, invasion and tube-like structure formation of human umbilical vein endothelial cells (HUVECs) with little toxicity. YF-452 inhibits VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase ( ERK ), focal adhesion kinase ( FAK ) and Src . YF-452 is a potential antiangiogenic agent candidate for cancer research.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cardiovascular Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > VEGFR

Product Information

• Catalog No.: HY-120200
• CAS No.: 1951466-83-3
• Molecular Formula: C24H26BrN3O
• Molecular Weight: 452.39
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source