PD 136450 (CAM 1189) is an antagonist for cholecystokinin 2 ( CCK2 ). PD 136450 exhibits anti-secretory, anxiolytic and anti-ulcer activities, inhibits gastric acid secretion ( IC 50 =1 mg/kg), and ameliorates the haemorrhagic lesions ( IC 50 =4.7 mg/kg) in rats.
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