SMU-B

Overview

SMU-B is the orally active inhibitor for ALK ( IC 50 <0.5 nM), c-ros oncogene 1 (ROS1), c-MET ( IC 50 =1.87 nM) and AXL ( IC 50 =28.9 nM). SMU-B inhibits the proliferation of MKN45, H1993 and H441 with IC 50 s of 0.02 μM, 1.58 μM and 2.82 μM, respectively. SMU-B exhibits antitumor efficacy in mouse models.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > ROS Kinase | Products > Signaling Pathways > Anaplastic lymphoma kinase (ALK) | Products > Signaling Pathways > TAM Receptor | Products > Signaling Pathways > c-Met/HGFR

Product Information

• Catalog No.: HY-120387
• CAS No.: 1253286-90-6
• Molecular Formula: C26H25Cl2FN4O2
• Molecular Weight: 515.41
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source