DS02312223

Overview

DS02312223 (D223) is a molecular glue that promotes the binding of RAS to PI3Kα , with a K d of 0.76 μM for p110α . DS02312223 increases the binding affinity between GTP-bound KRAS (KRAS-GMPPNP) and p110α by nearly three orders of magnitude ( K D = 0.017 μM). DS02312223 stimulates the translocation of GLUT4 to the plasma membrane. DS02312223 promotes glucose uptake in the absence of insulin . DS02312223 can be used in diabetes research.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Glucose Metabolism | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > GLUT | Products > Signaling Pathways > Molecular Glues | Products > Signaling Pathways > Ras | Products > Signaling Pathways > PI3K

Product Information

• Catalog No.: HY-W1126235
• CAS No.: 2253733-45-6
• Molecular Formula: C29H32FN5O5S
• Molecular Weight: 581.66
• Purity: 98.24%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source