XMU-MP-8

Overview

XMU-MP-8 (SKPer1) is a potent molecular glue degrader that targets the oncoprotein SKP2 . XMU-MP-8 simultaneously binds to the F-box domain of SKP2 ( K d ≈ 36 μM) and the N-terminal TPR domain of the E3 ligase STUB1 ( K d ≈ 2.5 μM), forming a stable SKP2-SKPer1-STUB1 ternary complex ( K d ≈ 8.9 nM) that induces SKP2 ubiquitination and proteasomal degradation. XMU-MP-8 selectively eliminates SKP2-expressing cancer cells. XMU-MP-8 exhibits substantial tumour suppression with good safety profiles in vivo. XMU-MP-8 can be used for cancer research, such as non-small cell lung adenocarcinoma (NSCLC) and prostatic adenocarcinoma.

Application

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Product Information

• Catalog No.: HY-W1128879
• CAS No.: 2271314-01-1
• Molecular Formula: C26H21F3N8S
• Molecular Weight: 534.56
• Purity: 99.23%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source