ONO-5334 is a potent, selective and orally active cathepsin K inhibitor with K i values of 0.10 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K , respectively. ONO 5334 is an effective antiviral compound against SAR-COV-2 virus activity with an EC 50 value of 500 nM. ONO-5334 has the potential for the study of osteoporosis and COVID-19 disease.
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