2,5-Dimethylcyclohexanol, a volatile organic compound, is a fatty acid that can be isolated from Amphora sp.. 2,5-Dimethylcyclohexanol has significant antineoplastic and antiviral activities with inhibition of SARS-CoV-2 Mpro . 2,5-Dimethylcyclohexanol also has potent antifungal activity against Pseudogymnoascus destructans . 2,5-Dimethylcyclohexanol compromises cell wall and membrane integrity while perturbing energy metabolism, increases the levels of ROS , ATP , Superoxide anion and GSH , and decreases CAT and SOD activities. And 2,5-Dimethylcyclohexanol alters virulence ribosomal genes expression, and disrupts the MAPK signaling pathways, inducing fungal cell apoptosis .
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