NCT02

Overview

NCT02 is a molecular glue degrader based on the E3 ubiquitin ligase DDB1 that targets CDK12 and its binding partner CCNK . NCT02 triggers the ubiquitination and proteasomal degradation of CCNK, thereby downregulating CDK12 protein levels and inhibiting its downstream signaling pathways. NCT02 can induce tumor cell apoptosis , arrest the cell cycle, and selectively inhibit the proliferation of colorectal cancer cells carrying TP53 defects or belonging to the consensus molecular subtype CMS4 . NCT02 has the potential to inhibit tumor growth in in vitro and in vivo models.

Application

Products | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > Molecular Glues | Products > Signaling Pathways > Ligands for E3 Ligase | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > CDK

Product Information

• Catalog No.: HY-W181530
• CAS No.: 790245-61-3
• Molecular Formula: C17H16N2O2S
• Molecular Weight: 312.39
• Purity: 98.14%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source