TMPO

Overview

TMPO (3,3,5,5-Tetramethyl-1-pyrroline 1-oxide) is a spin trap targeting free radicals . TMPO is capable of scavenging superoxide, hydroxyl radicals and inhibits thymocyte apoptosis with EC 50 values of 19.1 mM (MPS-induced) to 30.7 mM (Etoposide-induced) for inhibiting DNA fragmentation. TMPO reacts with intracellular free radicals to form stable nitroxide radical products, reducing oxidative stress (e.g., decreasing peroxide levels, maintaining glutathione content) and blocking oxidative events in the apoptotic pathway. TMPO is promising for research of apoptosis in immune cells like thymocytes.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-W271506
• CAS No.: 10135-38-3
• Molecular Formula: C8H15NO
• Molecular Weight: 141.21
• Purity: 99.87%
• Storage: Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source