Pyrazinoylguanidine

Overview

Pyrazinoylguanidine (PZG) is an analogue of the potassium sparing diuretic, Amiloride ( HY-B0285 ). Pyrazinoylguanidine can lower the systolic and diastolic blood pressure of patients with primary hypertension, has a certain effect on reducing heart rate, and does not affect the concentrations of electrolytes such as sodium, potassium, and chloride in the blood serum. Pyrazinoylguanidine can reduce the hyperglycemia and hyperinsulinemia in type 2 diabetes, reduce the levels of triglycerides, cholesterol , and free fatty acids, and reverse the hyperglycemia and hyperlipidemia induced by thiazide diuretics, such as Hydrochlorothiazide ( HY-B0252 ). Pyrazinoylguanidine ican nhibit the reabsorption of urea by the renal tubules, thereby increasing the clearance rate and excretion volume of urea, reducing the serum urea concentration, and minimizing its toxic accumulation.

Application

Products | Products > Disease Areas > Type 2 Diabetes | Products > Disease Areas > Hyperlipidemia | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Glucose Metabolism | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Hypertension | Products > Signaling Pathways > Others | Products > Research Areas > Metabolic Disease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Drug Derivative

Product Information

• Catalog No.: HY-W343043
• CAS No.: 60398-24-5
• Molecular Formula: C6H7N5O
• Molecular Weight: 165.15
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source