VPC 23019, an aryl amide-containing Sphingosine 1-phosphate (S1P) analog, is a competitive antagonist at the S1P1 and S1P3 receptors ( pK i = 7.86 and 5.93, respectively) and an agonist at the S1P4 and S1P5 receptors ( pEC 50 = 6.58 and 7.07, respectively).
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