TC-SP 14 (compound 14) is an orally active and potent S1P1 agonist ( EC 50 = 0.042 μM) with minimal activity at S1P3 ( EC 50 = 3.47 μM). TC-SP 14 significantly reduces blood lymphocyte counts and attenuates a delayed type hypersensitivity (DTH) response to antigen challenge.
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > LPL Receptor
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