Neospiramycin I

Overview

Neospiramycin I is a macrolide antibiotic and a derivative of Spiramycin I ( HY-N7141 ). Neospiramycin I is effective against the macrolide-sensitive KB210 strain of S. aureus , but ineffective against the macrolide-resistant KB224 strain, with minimum inhibitory concentrations ( MIC ) of 3.12 and greater than 100 µg/mL, respectively; it is also effective against B. cereus , B. subtilis , M. luteus , E. coli , and K. pneumoniae , with respective MIC values of 1.56, 3.12, 3.12, 0.2, 50, and 12.5 µg/mL. Neospiramycin I binds to the ribosomes of E. coli , with an inhibitory concentration 50 ( IC 50 ) of 1.2 µM. It protects mice from death in a type III S. pneumoniae infection model, with an effective dose 50 ( ED 50 ) of 399.8 mg/kg.

Application

Products | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Bacterial | Products > Signaling Pathways > Antibiotic

Product Information

• Catalog No.: HY-W587414
• CAS No.: 70253-62-2
• Molecular Formula: C36H62N2O11
• Molecular Weight: 698.88
• Purity: 96.27%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source