Glycolithocholic acid 3-sulfate disodium

Overview

Glycolithocholic acid 3-sulfate disodium is a GPR39 agonist with EC 50 s of 47.9 and 66.8 μM (absence of Zn 2+ ) and 8 and 8.7 μM (presence of Zn 2+ ) in M39-20 and hGPR39-2 cells, respectively. Glycolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn 2+ binding sites H17 and H19. Glycolithocholic acid 3-sulfate disodium also inhibits replication of HIV-1 in vitro . Glycolithocholic acid 3-sulfate disodium can be used for the research of HIV infection and gallbladder disease.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Viral Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Infection | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > HIV | Products > Signaling Pathways > GPR39

Product Information

• Catalog No.: HY-W587430
• CAS No.: 64936-82-9
• Molecular Formula: C26H41NNa2O7S
• Molecular Weight: 557.65
• Purity: 99.73%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 1 mg/mL (1.79 mM); Clear solution
• Availability: In-stock

Source

Original product source