RWJ-56110 dihydrochloride

Overview

RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC 50 =0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 ( IC 50 =0.16 μM) and thrombin ( IC 50 =0.34 μM), quite selective relative to U46619 ( HY-108566 ). RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell apoptosis .

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Protease Activated Receptor (PAR) | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-108556A
• CAS No.: 2387505-58-8
• Molecular Formula: C41H45Cl4F2N7O3
• Molecular Weight: 863.65
• Purity: 99.87%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 5 mg/mL (5.79 mM); Clear solution
• Availability: In-stock

Source

Original product source