4′-DTMP

Overview

4 '-DTMP is a DHFR inhibitor with Ki of 5.1 nM (DHFR WT ) and 34.3 nM (DHFR L28R ), respectively. 4 '-DTMP carries a polar modification that induces additional local interactions with the enzyme. In particular, the hairpin structure on the M20 ring is related to the internal communication of the DHFR. 4 '-DTMP has potential inhibition of E.coli.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Infection | Products > Signaling Pathways > Dihydrofolate reductase (DHFR)

Product Information

• Catalog No.: HY-W587663
• CAS No.: 21253-58-7
• Molecular Formula: C13H16N4O3
• Molecular Weight: 276.30
• Purity: 97.0%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source