N1-Acetyl-5-methoxykynuramine hydrochloride

Overview

N1-Acetyl-5-methoxykynuramine (AMK) hydrochloride is an active metabolite of the neurohormone melatonin ( HY-B0075 ). N1-Acetyl-5-methoxykynuramine hydrochloride (200 µM) effectively scavenges singlet oxygen ( ROS ).1 It also inhibits the production of prostaglandin E2 ( PGE2 ) and prostaglandin D2 ( PGD2 ) induced by epinephrine and arachidonic acid in a concentration- and time-dependent manner, and suppresses the increase in COX-2 levels induced by LPS ( HY-D1056 ) in RAW 264.7 macrophages at a concentration of 500 µM. In a mouse model of Parkinson's disease induced by MPTP ( HY-15608 ), N1-Acetyl-5-methoxykynuramine hydrochloride (20 mg/kg) reduces the increase in lipid peroxidation in the cytosol and mitochondria of the substantia nigra and striatum. N1-Acetyl-5-methoxykynuramine hydrochloride can be used in research on metabolic and neurological diseases

Application

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Product Information

• Catalog No.: HY-W587743
• CAS No.: 1215711-91-3
• Molecular Formula: C12H17ClN2O3
• Molecular Weight: 272.73
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source