4,8-Dioxa-3H-perfluorononanoic acid

Overview

4,8-Dioxa-3H-perfluorononanoic acid is an ether-substituted polyfluoroalkyl compound and also a ligand of human pregnane X receptor ( hPXR ), which binds to the ligand-binding domain of hPXR. 4,8-Dioxa-3H-perfluorononanoic acid targets Arg-410, Lys-210, Lys-226, Met-323 and His-327 residues. Its binding process relies on long-range electrostatic interactions, and no significant hydrogen bonds form with hPXR residues. 4,8-Dioxa-3H-perfluorononanoic acid is used as a substitute for PFOA in Germany. 4,8-Dioxa-3H-perfluorononanoic acid is detectable in environmental matrices such as river water near fluoride production plants , accumulates in organisms including grass, deer liver and locusts, and is present in plasma samples of populations in southern Germany.

Application

Products | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Female Reproductive System Disease | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Research Areas > Endocrinology | Products > Signaling Pathways > Pregnane X Receptor (PXR)

Product Information

• Catalog No.: HY-W587839
• CAS No.: 919005-14-4
• Molecular Formula: C7H2F12O4
• Molecular Weight: 378.07
• Purity: 99.98%
• Storage: Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Source

Original product source