ABS-752

Overview

ABS-752 is a potent and orally active GSPT1 and NEK7 molecular glue degrader. ABS-752 shows cytotoxicity. ABS-752 decreases the protein expression of GSPT1 and SALL4, NEK7 . ABS-752 is a prodrug activated by the monoamine oxidase , VAP-1 , to an aldehyde intermediate and subsequently to the active molecule, ABT-002 ( HY-175283 ). ABS-752 has the potential for the research of hepatocellular carcinoma.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Molecular Glues | Products > Signaling Pathways > NEKs

Product Information

• Catalog No.: HY-W599279
• CAS No.: 2761170-84-5
• Molecular Formula: C14H14FN3O3
• Molecular Weight: 291.28
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source