6-APDB

Overview

6-APDB is a class of monoamine neurotransmitter releaser and Monoamine Transporter modulator that exerts selective effects on human monoamine transporters and acts as a partial agonist at 5-HT 2 family receptors. For NET , 6-APDB has an IC 50 of 0.56 μM and a K i of 18 μM; for SERT , it has an IC 50 of 2.3 μM and a K i of 23 μM; for DAT , it has an IC 50 of 33 μM and a K i of >30 μM, and affinity for rat and mouse TAAR1, with K i values of 1.0 μM and 0.21 μM, respectively. 6-APDB inhibits norepinephrine and 5-HT reuptake , mediates the release of three types of monoamine neurotransmitters, shows a dose-dependent biphasic locomotor effect in mice, and fully substitutes the discriminative stimulus effect of MDMA . 6-APDB shows no significant cytotoxicity at high concentrations, and possesses empathogenic psychoactivity, potential hallucinogenic effects, and behavioral effects associated with intermittent abuse.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Monoamine Transporter | Products > Signaling Pathways > Serotonin Transporter | Products > Signaling Pathways > Dopamine Transporter | Products > Signaling Pathways > 5-HT Receptor

Product Information

• Catalog No.: HY-W680886
• CAS No.: 152623-93-3
• Molecular Formula: C11H15NO
• Molecular Weight: 177.24
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source