AF 353

Overview

AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. It is a highly potent inhibitor of α,β-meATP-evoked intracellular calcium flux in cell lines expressing recombinant rat and human P2X3 and human P2X2/3 channels. It also blocks human P2X2/3 channel function with marginally reduced potency (pIC50 = 7.3). It significantly reduces this parameter in both groups. It also reduces the inter-contractile interval in control but not in SCI rats.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cardiovascular and blood system | P2X Receptor

Product Information

• Catalog No.: B2693-459983
• CAS No.: 865305-30-2
• Molecular Formula: C14H17IN4O2
• Molecular Weight: 400.21
• Purity: >98%
• Storage: -20°C Freezer
• Solubility: DMSO: ≥ 32 mg/mL

Source

Original product source