Exherin

Overview

Exherin, also known as ADH-1, is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis. N-cadherin, a cell- surface transmembrane glycoprotein of the cadherin superfamily of proteins involved in calcium-mediated cell-cell adhesion and signaling mechanisms; may be upregulated in some aggressive tumors and the endothelial cells and pericytes of some tumor blood vessels. Sequence: Ac-Cys(1)-His-Ala-Val-Cys(1)-NH2 Source summary: Exherin is a peptide-related compound that disrupts cell adhesion, enhancing cancer research and therapeutic development. Inquire now to explore its potential applications.

Application

Products > Drug Discovery > Inhibitor > Other Inhibitors | Products > Drug Discovery > Inhibitor

Product Information

• Catalog No.: B2693-462516
• CAS No.: 229971-81-7
• Molecular Formula: C22H34N8O6S2
• Molecular Weight: 570.69
• Purity: 98%
• Storage: Store at -20°C
• Solubility: Soluble in DMSO

Source

Original product source