MRS2365 is a potent and selective P2Y1 receptor ( EC 50 =0.4 nM) / [ 35 S]GTPγS binding/ β-arrestin 2 recruitment agonist with an EC 50 of 0.4 nM. MRS2365 relieves mechanical allodynia and increases mechanical sensitivity. MRS2365 shows little agonist or antagonist activity at the P2Y12 or P2Y13 receptors.
Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > P2Y Receptor | Products > Signaling Pathways > Arrestin
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