NF157

Overview

NF157 is a highly selective nanomolar P2Y11 antagonist with a pK i of 7.35. The IC 50 s are 463 nM, 1811 µM, 170 µM for P2Y11 (K i =44.3 nM), P2Y1 (K i =187 µM), P2Y2 (K i =28.9 µM), respectively. NF157, significantly reduces expression of metalloproteinase ( MMP )-3, MMP-13 , can be used in the treatment of osteoarthritis (OA).

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > P2Y Receptor

Product Information

• Catalog No.: HY-108672
• CAS No.: 104869-26-3
• Molecular Formula: C49H28F2N6Na6O23S6
• Molecular Weight: 1437.10
• Purity: 99.13%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (1.74 mM); Clear solution
• Availability: In-stock

Source

Original product source