β-Selinene is a sesquiterpene and is the main active component of the essential oil of red purple hibiscus ( Callicarpa macrophylla ). β-Selinene exhibits significant related antioxidant activity, anti-inflammatory activity, and antipyretic analgesic activity. β-Selinene may exert antioxidant effects by directly scavenging free radicals ( DPPH , NO , •OH ) and chelating pro-oxidative metal ions (Fe²⁺); inhibit cyclooxygenase ( COX ) activity, reduce prostaglandin (such as PGE₂ ) synthesis to exert anti-inflammatory effects; regulate the thermoregulatory set point of the hypothalamus and inhibit inflammatory mediators to exert antipyretic and analgesic effects.
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