PPADS

Overview

PPADS is a P2X receptor ( P2X Receptor ) antagonist and a reversible competitive antagonist of NAADP receptors, with IC 50 values of 68 nM ( P2X1 ) and 214 nM ( P2X3 ), respectively. PPADS alleviates pain-related behaviors in the central and peripheral nervous systems of mice after peripheral neuropathy, inhibits the overproduction of IL-1β , IL-6 , iNOS and nNOS , and suppresses the hydrolytic activity of extracellular ATPase. PPADS blocks ATP-mediated inward currents on recombinant rat P2X 1 and P2X 3 receptors, and inhibits purinergic nerve stimulation-induced contraction of rabbit bladder detrusor muscle. PPADS is applicable to research related to neuropathic pain.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Pain | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > P2X Receptor | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-108960
• CAS No.: 149017-66-3
• Molecular Formula: C14H14N3O12PS2
• Molecular Weight: 511.38
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source