D-α-Hydroxyglutaric acid- 13 C 5 (disodium)

Overview

D-α-Hydroxyglutaric acid - 13 C 5 disodium is the 13 C-labeled D-α-Hydroxyglutaric acid ( HY-113038 ). D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K i of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling.

Application

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Product Information

• Catalog No.: HY-W779800
• CAS No.: 1648909-80-1
• Molecular Formula: 13C5H6Na2O5
• Molecular Weight: 197.04
• Purity: 98.87%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source