PF 05175157

Overview

PF-05175157 is a selective inhibitor of both acetyl-CoA carboxylase isoform ACC1 and isoform ACC2 dominant. IC50 values are 27 nM and 33 nM, respectively. It was originated by Pfizer. ACC inihibitors can inhibit de novo lipogenesis and increase β-oxidation of long-chain fatty acids. In Feb 2015, Phase-II for Type-2 diabetes mellitus in USA was discontinued. Source summary: PF 05175157 is a research-use small-molecule compound for biochemical and pharmacology studies; explore its properties and applications.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Endocrinology and Metabolic Disease | ACC

Product Information

• Catalog No.: B2693-475284
• CAS No.: 1301214-47-0
• Molecular Formula: C23H27N5O2
• Molecular Weight: 405.50
• Purity: 98%
• Storage: -20°C Freezer
• Solubility: Soluble to 5 mg/mL in DMSO

Source

Original product source