Otaplimastat (SP-8203) hydrobromide, a matrix metalloproteinase ( MMP ) inhibitor, blocks N-methyl-D-aspartate (NMDA) receptor -mediated excitotoxicity in a competitive manner. Otaplimastat hydrobromide also exhibits anti-oxidant activity. Otaplimastat hydrobromide can be used for the research of brain ischemic injury.
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