(Rac)-Upacicalcet

Overview

(Rac)-Upacicalcet is the racemate of Upacicalcet ( HY-109106 ). Upacicalcet is a non-peptide calcimimetic that acts as a CaSR agonist ( EC 50 = 10.8 nM). Upacicalcet reduces serum intact parathyroid hormone (iPTH) and serum Ca2+ levels, reducing hypocalcemia and gastrointestinal complications. Upacicalcet improves vascular calcification and bone disorders in the Adenine ( HY-B0152 )-induced secondary hyperparathyroidism (SHPT) rat model. Upacicalcet inhibits cortical pore formation and reduces bone fibrosis in rats with chronic kidney disease (CKD). Upacicalcet is useful for studying SHPT.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Endocrinology | Products > Signaling Pathways > CaSR

Product Information

• Catalog No.: HY-109106B
• CAS No.: 2649575-19-7
• Molecular Formula: C11H14ClN3O6S
• Molecular Weight: 351.76
• Purity: 95.0%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source