Agmatine is an orally active analgesic that can cross the blood-brain barrier. Agmatine targets the 5-HT 2A receptor, 5-HT 3 receptor, α 2 -adrenergic receptor, and I1 imidazoline receptor . Agmatine produces dose-dependent analgesic effects in various pain models. Agmatine can be used in research related to visceral pain, neuropathic pain, and inflammatory pain.
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