Copper (I) oxide is an oxidative stress inducer and cytotoxic agent. Copper (I) oxide causes dose-dependent decrease in the viability of airway epithelial cells by impairing the activities of catalase and glutathione reductase , generating reactive oxygen species , and increasing the levels of 8-isoprostane and the ratio of oxidized glutathione. However, when combined with Resveratrol ( HY-16561 ), the cytotoxic effect induced by Copper (I) oxide is significantly attenuated, and oxidative damage is effectively alleviated.
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