Pivaloyloxymethyl chloride

Overview

Pivaloyloxymethyl chloride is an organic intermediate used to introduce the pivaloyloxymethyl ( POM ) protecting group, and it can be prepared from trimethylacetic acid and chloromethyl chlorosulfonate as raw materials . Pivaloyloxymethyl chloride is an alkylating reagent for the synthesis of phosphonic acid prodrugs; the introduction of the hydrophobic POM group enhances the lipid solubility and membrane permeability of molecules. Pivaloyloxymethyl chloride can be used in the synthesis of tetrakis (pivaloyloxymethyl) methylenebisphosphonate, which is a precursor of the pivaloyloxymethyl clodronate prodrug. Pivaloyloxymethyl chloridecan support the synthesis of aryl/pivaloyloxymethyl mixed phosphonate prodrugs of butyrophilin 3A1 ligands.

Application

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Product Information

• Catalog No.: HY-Y0643
• CAS No.: 18997-19-8
• Molecular Formula: C6H11ClO2
• Molecular Weight: 150.60
• Purity: 99.98%
• Storage: Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source