DL-Menthol (Racementhol) is an orally active, GABA a R positive allosteric modulator and UDP-glucuronosyltransferase ( UGT ) inhibitor that can cross the blood-brain barrier. DL-Menthol binds to GABA A R and exhibits an allosteric activation effect, enhancing GABA-mediated chloride influx and inhibiting neuronal excitability. DL-Menthol can induce surgical anesthesia in fish and inhibit the metabolic detoxification of tobacco carcinogens by human liver and intestinal UGT enzymes, resulting in reduced NNAL-N-Gluc production.
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