Dehydronitrosonisoldipine

Overview

Dehydronitrosonisoldipine, a derivative of Nisoldipine ( HY-17402 ), is an irreversible and cell-permeant sterile alpha and TIR motif-containing 1 (SARM1) inhibitor. Dehydronitrosonisoldipine acts mainly by blocking SARM1 activation but not its enzymatic activities. Dehydronitrosonisoldipine inhibits SARM1 and axon degenration (AxD) by covalently modifying cysteines, also inhibits the Vincristine-activated cADPR production in neurons. Dehydronitrosonisoldipine can be used for researching neurodegenerative disorders.

Application

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Product Information

• Catalog No.: HY-Z0816
• CAS No.: 87375-91-5
• Molecular Formula: C20H22N2O5
• Molecular Weight: 370.40
• Purity: 98.86%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 3 mg/mL (8.10 mM); Clear solution
• Availability: In-stock

Source

Original product source