Ixabepilone

Overview

Ixabepilone (also known as azaepothilone B, or BMS-247550) is an orally bioavailable microtubule inhibitor. Ixabepilone was a semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Ixabepilone was approved in 2007.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Neurological Disease | Microtubule/Tubulin

Product Information

• Catalog No.: B0084-063099
• CAS No.: 219989-84-1
• Molecular Formula: C27H42N2O5S
• Molecular Weight: 506.7
• Purity: >98%

Source

Original product source