Olaparib

Overview

Olaparib, also known as AZD-2281 or KU-59436, is a small-molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Olaparib selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks.

Application

Products > Drug Discovery > Impurities > Anti-Neoplastic > Olaparib and Impurities | Products > Drug Discovery > Inhibitor

Product Information

• Catalog No.: B0084-076683
• CAS No.: 763113-22-0
• Molecular Formula: C24H23FN4O3
• Molecular Weight: 434.471
• Purity: >98%

Source

Original product source