AG-879

Overview

AG-879, a tyrphostin compound, is a dual EGFR/HER2 inhibitor that was administered together with androgen withdrawal therapy. It inhibits nerve growth factor (NGF)-dependent TrkA tyrosine phosphorylation in PC-12 cells (IC50 = ~40 μM), HER2-ErbB2 kinase in several breast and ovarian cancer cell lines (IC50 = ~0.5 μM), and the VEGF receptor FLK1 (IC50 = ~1 μM).

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cardiovascular and blood system | EGFR

Product Information

• Catalog No.: B0084-195953
• CAS No.: 148741-30-4
• Molecular Formula: C18H24N2OS
• Molecular Weight: 316.5
• Solubility: DMSO to 100 mM; ethanol to 25 mM

Source

Original product source