Tofacitinib

Overview

Tofacitinib is an orally available JAK3 inhibitor (IC50 = 1 nM), exhibiting 20- and 100-fold less potency against JAK2 and JAK1. Tofacitinib induces G1 cell cycle arrest and inhibits tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells. It is approved for the treatment of rheumatoid arthritis (RA).

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Inflammation / Immunology | JAK

Product Information

• Catalog No.: B0084-453466
• CAS No.: 477600-75-2
• Molecular Formula: C16H20N6O
• Molecular Weight: 312.37
• Purity: >98%

Source

Original product source