RKI-1447

Overview

RKI-1447 is a potent Rho-associated kinase (ROCK) inhibitor with IC50 values of 14.5 and 6.2 nM for ROCK1 and ROCK2 respectively. It exhibits significant anti-invasive and antitumor activity in breast cancer. In combination with fasudil, it was shown to induce differentiation of mESCs and hESCs to endoderm via ROCK inhibition.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cardiovascular and blood system | ROCK

Product Information

• Catalog No.: B0084-462699
• CAS No.: 1342278-01-6
• Molecular Formula: C16H14N4O2S
• Molecular Weight: 326.374
• Purity: >98%

Source

Original product source