Bavachinin

Overview

Bavachinin is a natural compound isolated from the Chinese herb Fructus Psoraleae. Bavachinin has potent anti-angiogenic activity in vitro and in vivo. Bavachinin inhibited increases in HIF-1α activity in human KB carcinoma (HeLa cell derivative) and human HOS osteosarcoma cells under hypoxia in a concentration-dependent manner, probably by enhancing the interaction between von Hippel-Lindau (VHL) and HIF-1α. It significantly inhibited Th2 cytokine production, including IL-4, IL-5 and IL-13. Notably, this compound almost completely blocked inflammation in the ovalbumin (OVA)-sensitized animal asthma model.

Application

Products > Chemistry > Natural Compounds | Products > Drug Discovery > Inhibitor | Flavonoids

Product Information

• Catalog No.: B2703-173139
• CAS No.: 19879-30-2
• Molecular Formula: C21H22O4
• Molecular Weight: 338.4
• Purity: >98%

Source

Original product source