Sulfathiourea is an inhibitor of Pneumocystis carinii dihydropteroate synthetase ( dihydropteroate synthetase ), with an IC 50 of 0.022 μM and a K i of 16.5 nM. Sulfathiourea blocks folate biosynthesis by inhibiting the enzyme that links 7,8-dihydro-6-hydroxymethylpterin pyrophosphate with p-aminobenzoic acid to form dihydropteroate. Sulfathiourea can be used in research related to *Pneumocystis carinii* pneumonia.
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