PDE5-IN-1

Overview

PDE5-IN-1 is an orally active, selective PDE5 inhibitor with an IC 50 of 5.6 nM. PDE5-IN-1 forms hydrogen bond interactions with the Q817 residue in the catalytic domain of PDE5 , and aromatic π-π stacking interactions with the F820 residue. PDE5-IN-1 exerts anti-cardiac hypertrophy and vasodilatory effects, reduces mean pulmonary arterial pressure and right ventricular hypertrophy index. PDE5-IN-1 can be used in the research of pulmonary arterial hypertension.

Application

Products | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Pulmonary Hypertension | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Phosphodiesterase (PDE)

Product Information

• Catalog No.: HY-103084
• CAS No.: 2109805-65-2
• Molecular Formula: C22H14N2O4S
• Molecular Weight: 402.42
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source